The University of Utah’s (U of U’s) Digital Health Initiative (DHI) aims to transform health care and bring joy to patients and healthcare teams across the nation through disruptive digital innovations. DHI will leverage the U of U’s world-renowned expertise in playful engagement, standards-based interoperability, and participatory design. DHI serves as a hub and catalyst for research, promoting the development and commercialization of transformative digital technologies. With past and current collaborations across the health science and main campus, public and private institutions in the state, and national and international partners in both academia and private industry, DHI establishes the U of U as one of the leading institutions, if not the leading institution, in the rapidly growing field of digital health. DHI aims to achieve the quintuple aim of health care: a joyful patient experience, improved outcomes, affordable and accessible health care, a flourishing work environment for clinical care teams, and health equity.